Measuring tape on woman's waist wearing black leggings and black sportsbra: Life Extension Europe

AMPK

How to lose belly fat? AMPK is known as a master regulator of metabolism.

AMPK is an enzyme found in every cell in your body, telling your cells to stop storing fat and start burning it for energy, especially around the abdomen. 

Over time, declining AMPK levels can cause the accumulation of abdominal fat.